ALDI
(Alzheimer’s Disease)
qPCR SNP Detection Kit
Description
Having an unfavourable variant of the analysed genes is the strongest genetic risk factor for Alzheimer’s disease and is associated with impairment of cerebral metabolism and cerebrovascular function. The classic development of the disease may begin long before the first symptoms appear, most often cognitive impairment.
REF. NUMBER
755SNP451pah
PREDISPOSITION
Alzheimer’s Disease
ANALYSED GENES
APOE, TREM2
IDENTIFIED POLYMORPHISMS
rs75932628, rs429358, rs7412
KIT CONTENTS
4 × Nuclease-Free Water
4 × 2xSNP MasterMix
4 × Oligos Set
2 × Positive Control Set
QUANTITY
100 rxns
STORAGE CONDITIONS
-25°C to -15°C
CERTIFICATES
More Information
Did you know...?
Alzheimer’s disease is mainly manifested by cognitive impairments concerning memory, emotions, and learning abilities. The development of the disease causes a gradual and irreversible degeneration and death of nerve cells in the brain. It progresses slowly and is not noticeable at first. Symptoms are usually attributed to age-related changes.
What are the symptoms and risk factors?
Alzheimer’s disease is characterised by: short-term memory and learning disabilities, problems with performing tasks requiring memory and concentration, gradual deterioration of long-term memory, language disorders. Alzheimer’s disease is multifactorial and usually occurs after several factors have overlapped. Environmental risk factors for developing the disease: old age, over 65 years, low level of social contact, a history of head trauma. The predisposition to the disease also depends on the genetic variant.
How the test is performed?
The test we offer examines the risk of developing the disease based on mutations found in two genes: APOE and TREM2. TREM2 and APOE genes are DNA fragments that contain instructions for building proteins that contribute to normal brain functioning and are involved in the development of Alzheimer’s disease. The real-time PCR method used for the analysis of polymorphisms allows for precise and quick identification of the genotype.
How will the client benefit?
The kit we offer contains ready-to-use reagents, which, when added in the right proportions, are ready for reaction. The product IFU included in the kit allows easy interpretation of the obtained data. The client receives a genetic report with a description of his genotype and a detailed explanation and recommendations tailored to his individual genetic profile. Recommendations indicate to the client the further diagnostic path and preventive measures.
Why is it worth doing a genetic test?
In the case of Alzheimer’s disease, an early diagnosis means a better response to treatment. The offered test provides the client with a precise analysis of genes that will allow him to take appropriate steps to improve his health. The test result will also be useful to plan an effective treatment strategy individually tailored to the patient.
What can be done after the test result?
In the case of an unfavorable variant of the gene, it is important to follow the recommendations and consult a doctor. It should be remembered that a normal genotype does not exclude the disease. The great potential of genetic testing makes it possible to predict many diseases and gives a chance to take action to improve the patient’s health.