PADI
(Parkinson’s Disease)
qPCR SNP Detection Kit
Description
Changes in the analysed gene result in defects in communication between nerve cells in the brain, which translates into the characteristic hand tremors and other symptoms of Parkinson’s disease.
REF. NUMBER
755SNP451ppk
PREDISPOSITION
Parkinson’s Disease
ANALYSED GENE
SNCA
IDENTIFIED POLYMORPHISMS
rs356219, rs2736990
KIT CONTENTS
2 × Nuclease-Free Water
2 × 2xSNP MasterMix
2 × Oligos Set
2 × Positive Control Set
QUANTITY
100 rxns
STORAGE CONDITIONS
-25°C to -15°C
CERTIFICATES
More Information
Did you know...?
Parkinson’s disease is one of the most common degenerative diseases of the nervous system. It is caused by the loss of cells that produce the neurotransmitter (dopamine) in the substantia nigra pars compacta, the area responsible for coordinating involuntary and rapid movements. The main symptoms of Parkinson’s disease: resting tremor, muscular rigidity (characteristic resistance to passive movement of a limp), slowed movement (characterized by difficulty in starting the movement), the sudden interruption of movement that has already begun, lack of facial expression.
What are the risk factors?
Natural risk factors for developing the disease are age (over 60) and gender (men are more likely to be affected), as well as family history of the disease (genetic factor). Other probable risk factors include head trauma, depression, occupational pesticide exposure, and chronic constipation. The disease is multifactorial and usually occurs when several of these factors overlap. Parkinson’s disease also has a genetic background.
How the test is performed?
The SNCA gene is a DNA fragment that contains instructions for building a protein that plays a role in the functioning of nerve cells in the brain and is associated with the development of Parkinson’s disease. The test performed focused on two specific positions in the gene where changes (mutations) can occur. The variant of the SNCA gene is identified using the real-time PCR molecular method.
How will the client benefit?
The technique used to analyze the studied polymorphisms ensures precise determination of the genotype, and thus the risk of developing Parkinson’s disease. Thanks to the ready-to-use reagents included in the kit, the preparation of the reaction mixture is quick, easy and does not require much work. Basing on the test result and the decision matrix in the product IFU, the client will receive precise information about their gene variant and a brief explanation of what it means. The result is also accompanied by recommendations tailored to the client’s genetic profile.
Why is it worth doing a genetic test?
The availability of a genetic test gives each person a chance to learn about their individual predispositions and to take possible actions to avoid the disease. Professional approach and individual recommendations indicating further procedure and diagnostic path will encourage the client to continue obtaining information about his DNA and disease predispositions.
What can be done after the test result?
In the case of an unfavorable variant of the gene, it is important to follow the recommendations and consult a doctor. It should be remembered that a normal genotype does not exclude the disease. The great potential of genetic testing makes it possible to predict many diseases and gives a chance to take action to improve health.