PSORI
(Psoriasis)
qPCR SNP Detection Kit
Description
The HLACw06*02 gene influences the formation of psoriasis, and mutation detection is also useful in differentiating psoriatic arthritis from rheumatoid arthritis (RA), ankylosing spondylitis (AS) and osteoarthritis. Psoriasis is a chronic, systemic disease with characteristic dermatological changes. It has an autoimmune background and can begin at any age, but most often (in about 85% of patients) it begins before the age of 30.
REF. NUMBER
755SNP451pps
PREDISPOSITION
Psoriasis
ANALYSED GENE
HLA-Cw*0602
IDENTIFIED POLYMORPHISM
rs4406273
KIT CONTENTS
1 × Nuclease-Free Water
1 × 2xSNP MasterMix
1 × Oligos Set
1 × Positive Control Set
QUANTITY
100 rxns
STORAGE CONDITIONS
-25°C to -15°C
CERTIFICATES
More Information
Did you know...?
Psoriasis is a chronic, systemic disease with characteristic dermatological changes. This disease is autoimmune and may begin at any age, most often (in about 85% of patients) it begins before the age of 30. The disease has many subtypes and forms of varying intensity and degree of development.
What are the symptoms of psoriaris?
Psoriasis manifests as areas of reddened skin covered with a silver-white scales (the so-called Koebner’s symptom). Characteristic for this dermatosis is also the Auspitz symptom, which consists in the occurrence of bleeding at the scratch site, or the stearin candle symptom, which consists in the appearance of an effect similar to the application of a thin layer of stearin at the scratched husk site.
How the test is performed?
The test is based on the real-time PCR method, which enables precise determination of the patient’s genotype. The incidence of psoriasis has been linked to the identification of the HLA-Cw06*02 gene. The HLA-Cw06*02 gene is a DNA fragment that contains instructions for building a protein responsible for the development of disease.
How will the client benefit?
The test offered enables the determination of the patient’s genotype within a short time and minimum lab work. Analysis of the results based on the matrix contained in the IFU product, provides clear information about the patient’s gene variant and provides individual recommendations to the patient depending on the examined polymorphism.
Why is it worth doing a genetic test?
The disease can appear only in genetically predisposed people. The risk of developing and inheriting this dermatosis increases with the presence of mutation. Awareness of the risk allows for early diagnosis and start of treatment that will alleviate the symptoms of psoriasis. The test result may be useful in differentiating psoriasis from other diseases, therefore the test may be ordered by clinicians.
What can be done after the test result?
In the case of an unfavorable variant of the gene, it is important to follow the recommendations and consult a doctor. Based on the result and the clinical presentation, the doctor will achieve an accurate diagnosis and select the appropriate treatment strategy. The great potential of genetic testing makes it possible to predict many diseases and gives a chance to take action to improve health.